Another Dark Little Corner
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Started this before change to "New Blogger", as backup in case of trouble with digiphoto blog "In a Small Dark Room", or rants & links blog "Hello Cruel World" . Useful - at one stage Dark Room was there, but like the astrophysical Dark Matter, we could't see it ... better now, but kept Just In Case.
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2004-07-13
A good use for genetic manipulation techniques Flies help unlock the secrets to diseases such as Alzheimer's By Michael Bradley July 13, 2004 http://www.smh.com.au/articles/2004/07/12/1089484306328.html Scientists have found a way of successfully treating flies that were given human degenerative brain diseases. The Genetic Society of Australia conference in Melbourne yesterday heard how an insect best known for its insatiable appetite for rotting fruit has been catapulted to the forefront of attempts to prevent and cure conditions such as Alzheimer's, Parkinson's and Huntington's diseases. US researchers have identified the human genes responsible for brain degeneration and put them into the humble vinegar fly. Nancy Bonini, a biologist at the University of Pennsylvania, said: "What these mutant genes do is give the fly something which very much looks like Alzheimer's, Parkinson's or Huntington's disease. More importantly, Dr Bonini said she had identified compounds capable of controlling these conditions in the insects. Dr Bonini has spent more than six years working with the impaired flies. She said geldanamycin - a naturally occurring compound that is being trialled as an anti-tumour agent in humans - had been shown to stimulate genes in the fly that helped its body in times of high stress. "We gave the flies these compounds and, as a result, it prevented the build-up of plaque in the fly's brain and stopped their degeneration," Dr Bonini said. "What we have really done is use fly genetics to prevent these diseases." About 162,000 Australians suffer from some form of dementia or brain degeneration. A report by Alzheimer's Australia titled The Dementia Epidemic estimates that more than 500,000 people will suffer from dementia by 2041 [I assume this means 500,000 in Australia.]
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